| 合成萘丁美酮的新方法 |
| |
| 引用本文： | 尤田耙,胡卫浩.合成萘丁美酮的新方法[J].中国医药工业杂志,1996,27(8):339-340. |
| |
| 作者姓名： | 尤田耙 胡卫浩 |
| |
| 作者单位： | 中国科学技术大学化学系 |
| |
| 摘 要： | β－萘甲醚在ＡｌＣｌ３存在下与丙烯腈反应，生成３－（６－甲氧基－２－萘基）丙腈；再与ＣＨ３Ｃｌ的格氏试剂反应，产物经水解得萘丁美酮。两步反应总产率约４５％。
|
| 关 键 词： | 萘丁美酮，合成，丙烯腈，格氏试剂 |
NOVEL SYNTHESIS OF NABUMETONE |
| |
| Authors: | YOU Tian-Pa HU Wei-Hao PAN Xian-Dao |
| |
| Abstract: | A novel route for synthesis of nabumetone under mild condition was described.2-Methoxynaphthalene reacted with acrylonitrile to form 3-(6-methoxy-2-naphthyl) propionitrile(3),then 3 was converted to nabumetone by addition of methyl magnesium chloride. The overall yield is 45% |
| |
| Keywords: | nabumetone synthesis acrylonitrle Grignard reagent |
| 本文献已被 CNKI 维普 等数据库收录！ |
