| 重组链激酶对大鼠凝血功能的影响及其毒性 |
| |
| 引用本文： | 施安国,邓中平.重组链激酶对大鼠凝血功能的影响及其毒性[J].中国医药工业杂志,1996,27(7):310-312. |
| |
| 作者姓名： | 施安国 邓中平 |
| |
| 作者单位： | 上海医药工业研究院毒理室，上海医科大学分子遗传研究室 |
| |
| 摘 要： | 重组链激酶以６、３０、１５０万ＩＵ／ｋｇ的剂量水平给大鼠腹腔注射，观察毒性反应。给药２８ｄ时，除各给药组凝血功能与对照组相比有不同程度的降低之外，其他无明显的毒性反应。凝血功能改变与剂量有关，并在停药１４ｄ后恢复，结果表明重组链激是一个毒性低的溶栓药。
|
| 关 键 词： | 链激酶，重组链激酶，抗体，大鼠，凝血 |
EFFECT ON BLOOD COAGULATION FUNCTION AND TOXICITY OF RECOMBINANT STREPTOKINASE IN RATS |
| |
| Authors: | SHI An-Guo DENG Zhong-Ping REN Jun |
| |
| Institution: | Shanghai Institute of Pharmaceutical Industry. Shanghat 200137; Dept of Molecular Genetics. Shanghai Medical University. Shanghai 200032 |
| |
| Abstract: | Three dose levels of r-SK (60000, 300000 and 1500000 IU/kg)were given ip to rats for 28 consecutive days respectively to observe the toxicity of r-SK, a similar group served as a control. The results showed that there were no obvious toxicities on day 28 except some changes in blood coagulation, and these changes were dose-related and reversible in rest period of two weeks. Our results proved that r-SK was a less toxic thrombolytic drug. |
| |
| Keywords: | streptokinase(SK) recombinant streptokinase(r-SK) antibody rat blood coag ulation |
| 本文献已被 CNKI 维普 等数据库收录！ |
