化疗药物引起消化道肿瘤患者肝损伤的临床分析

目的:研究化疗药物对消化道肿瘤患者肝功能影响,并对其引起肝损伤相关因素进行分析总结。方法:回顾性分析某院2008年1月-2010年12月3年间确诊为化疗药物性肝损伤患者40例,统计分析化疗前后谷丙转氨酶(ALT),谷草转氨酶(AST),碱性磷酸酶(ALP),总胆红素(TBIL)。结果:共收集1度肝损伤患者31例,2度和3度肝损伤患者共9例。40例消化道肿瘤患者化疗后ALT、AST、TBIL指标显著高于化疗前(P<0.05);肝损伤持续时间>4周的患者ALT、AST肝功能指标高于持续时间<4周的患者(P<0.05);年龄、性别、合并肝胆基础疾病、携带乙肝病毒、肿瘤类型等相关因素对肝功能无显著影响(P>0.05)。结论:消化道肿瘤患者的化疗药物性肝损伤以轻度损伤为主,肝损伤持续时间越长,肝功能损害越严重。年龄、性别、合并肝胆基础疾病、携带乙肝病毒、肿瘤类型等因素对肝功能无显著影响。

Clinical analysis of chemotherapeutic drug-induced liver injury in patients with digestive tract cancer

OBJECTIVE To study on the influence of chemotherapeutic drug on liver functions in patients with digestive tract cancer patients and analyze the correlative factors of liver-injury caused by chemotherapeutic drug.METHODS 40 cases of patients with digestive tract cancer in our hospital diagnosed as chemotherapy hepatotoxicity were analyzed restrospectively from 2008 January to 2010 March.Liver functions of ALT,AST,ALP and TBIL were studied.RESULTS 31 cases of liver injury were involved in Grade 1,9 cases were in Grade 2 and 3.Liver functions of ALT,AST,TBIL before chemotherapy were significantly higher than that after chemotherapy(P<0.05).Serum ALT,AST in patients who had got more than four weeks’ liver injury increased higher than that in patients who had not(P<0.05).Relative factors of age,sex,hepatobiliary diseases,hepatitis B virus,types of cancers were not significantly associated with chemotherapy hepatotoxicity in digestive tract cancer(P>0.05).CONCLUSION Most of patients who developed hepototoxicity in digestive tract cancer are miled.The longer duration of liver injury is,the worse liver functions are.Relative factors of age,sex,hepatobiliary diseases,hepatitis B virus,types of cancers are not significantly associated with chemotherapy hepatotoxicity.