Adherence to Highly Active Antiretroviral Therapy Among Children in Ethiopia: A Systematic Review and Meta-analysis |
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| Authors: | Aklilu Endalamaw Nega Tezera Setegn Eshetie Sintayehu Ambachew Tesfa Dejenie Habtewold |
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| Affiliation: | 1.Department of Pediatrics and Child Health Nursing, School of Nursing, College of Medicine and Health Sciences,University of Gondar,Gondar,Ethiopia;2.Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences,University of Gondar,Gondar,Ethiopia;3.Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences,University of Gondar,Gondar,Ethiopia;4.University Center for Psychiatry, Rob Giel Research Centre,University of Groningen, University Medical Center Groningen,Groningen,The Netherlands;5.Department of Epidemiology,University of Groningen, University Medical Center Groningen,Groningen,The Netherlands |
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| Abstract: | Adherence to highly active antiretroviral therapy (HAART) is the mainstay of the strategy in reducing morbidity and mortality of HIV-infected children. Different primary studies were conducted in Ethiopia. Thus, we aimed to conduct a meta-analysis of the national prevalence of optimal adherence to HAART in children. In addition, associated factors of HAART adherence were reviewed. A weighted inverse variance random-effects model was applied. The 88.7 and 93.7% of children were adhering to HAART at 07 and 03 days prior to an interview respectively. The subgroup analysis showed that HAART adherence was 93.4% in Amhara, 90.1% in Addis Ababa and 87.3% in Tigray at 07 days prior to an interview. Our study suggests that, within short window reported time, adherence to HAART in Ethiopian children may be in a good progress. Emphasis on specific adherence interventions need further based on individual predictors to improve overall HAART adherence of children. |
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