Longitudinal Effects of Syndemics on ART Non-adherence Among Sexual Minority Men |
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Authors: | Audrey Harkness Sierra A. Bainter Conall O’Cleirigh Noelle A. Mendez Kenneth H. Mayer Steven A. Safren |
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Affiliation: | 1.Department of Psychology,University of Miami,Miami,USA;2.Fenway Community Health,The Fenway Institute,Boston,USA;3.Department of Psychiatry,Harvard Medical School/Massachusetts General Hospital,Boston,USA;4.Division of Infectious Disease, Department of Medicine,Harvard Medical School/Beth Israel Deaconess Medical Center,Boston,USA |
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Abstract: | This study examined longitudinally the additive effect of syndemics, or co-occurring psychosocial problems, on antiretroviral treatment (ART) non-adherence among 390 HIV-positive sexual minority men. Participants completed measures of ART adherence (reduced to a non-adherence score using exploratory factor analysis) and six syndemic conditions. We employed multilevel modeling with the number of syndemics as a longitudinal predictor of non-adherence, and logistic regression with baseline syndemics predicting follow up viral load. Number of syndemics was a significant longitudinal predictor of non-adherence, with each additional syndemic associated with a 0.13 increase in non-adherence (p?=?0.004). Each additional syndemic was also associated with 1.27 greater odds of detectable viral load (p?=?0.002). Among HIV-positive sexual minority men in this sample, more syndemics were associated with lower ART adherence and greater odds of detectable viral load, suggesting the need for behavioral intervention to facilitate care for this population. |
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