Lipid composition and grafted PEG affect in vivo activity of liposomal mitoxantrone |
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Authors: | Li ChunLei Cui JingXia Wang CaiXia Wang JinXu Li YanHui Zhang Lan Zhang Li Guo WenMin Wang YongLi |
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Institution: | ZhongQi Pharmaceutical Technology (Shijiazhuang) Co., Ltd., No. 276, ZhongShan West Road, Shijiazhuang City, Hebei Province 050051, PR China. |
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Abstract: | Mitoxantrone was encapsulated into pegylated SUVs using ammonium sulfate gradient method. Four formulations (LM-s, LM-p, LM-m and LM-m-L) were prepared, which were made from different PCs and exhibited different PEG grafting density. In vitro release studies revealed that drug release rate increased with decreased T(m) of PCs, and reduced PEG polymer coverage. In circulation, the trend towards increased circulation time as T(m) of PCs and PEG lipid content are elevated is observed. However, it was found that the order of toxicity in balb/c mice was Lm-s
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