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阿托伐他汀治疗颈动脉粥样硬化斑块的临床研究
引用本文:王蕾,高励.阿托伐他汀治疗颈动脉粥样硬化斑块的临床研究[J].四川医学,2010,31(2):194-196.
作者姓名:王蕾  高励
作者单位:成都市第三人民医院神经内科,四川,成都,610031
摘    要:目的研究阿托伐他汀对颈动脉粥样硬化斑块的疗效。方法应用彩色多普勒超声检出颈动脉粥样硬化斑块形成者259例,随机分为对照组(常规治疗)和治疗组(常规治疗加口服阿托伐他汀),观察治疗前后颈动脉内膜中层厚度(IMT)、斑块回声性质、大小的变化,并与对照组比较。结果治疗组和对照组6个月IMT分别为(0.914±0.069)和(1.1±0.141),12个月IMT分别为(0.829±0.076)和(1.114±0.16),两组比较差异有统计学意义(P〈0.05)。斑块数量治疗组和对照组比较差异无统计学意义(P〉0.05),斑块的大小低于治疗前,但与对照组比较差异无统计学意义。治疗组斑块的厚度较对照组和治疗前均有变薄,治疗12个月差异有统计学意义。软斑数量治疗组较对照组也有减少,差异有统计学意义。结论阿托伐他汀具有隐定和缩减颈动脉粥样硬化斑块的作用,能减缓颈动脉粥样硬化的进展,而且随着治疗时间的延长,抗动脉粥样硬化及稳定斑块的作用更加明显。

关 键 词:颈动脉粥样硬化斑块  彩色多普勒超声  阿托伐他汀

Clinical study of atorvastatin therapy in patients with carotid atherosclerosis plaques
WANG Lei,GAO Li.Clinical study of atorvastatin therapy in patients with carotid atherosclerosis plaques[J].Sichuan Medical Journal,2010,31(2):194-196.
Authors:WANG Lei  GAO Li
Institution:WANG Lei,GAO Li.The Third Hospital of Chengdu,Chengdu,Sichuan 610031,China
Abstract:Objective To investigate the effects of atorvastatin on carotid atherosclerosis plaques.Methods 259 patients with carotid atherosclerosis plaques were selected,and they were divided into atorvastatin(20 mg/d) group (treatment group,n = 123) and control group(without atorvastatin,n = 129).6,12 months after the treatment.The intima-media thickness(IMT)of bilateral carotid arteries and plaque morphology were evaluated with carotid ultrasound examination.Results The IMT in the treatment and control groups at 6 ...
Keywords:carotid atherosclerosis plaque  doppler ultrasonography  atorvastatin  
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