Mesangiocapillary glomerulonephritis associated with meningococcal meningitis,C3 nephritis factor and persistently low complement C3 and C5 |
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| Authors: | Sally-Anne Hulton R. Anthony Risdon Michael J. Dillon |
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| Affiliation: | (1) Department of Paediatric Nephrology, Institute of Child Health, Great Ormond Street, WC1N 3JH London, UK;(2) Department of Histopathology, Institute of Child Health, Great Ormond Street, WC1N 3JH London, UK;(3) The Hospital for Sick Children, Great Ormond Street, WC1N 3JH London, UK;(4) Department of Paediatric Nephrology, Institute of Child Health, 30 Guilford Street, WC1N 1EH London, UK |
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| Abstract: | We report two unusual cases in which mesangiocapillary glomerulonephritis occurred in association with meningococcal infection. C3 nephritic factor, an autoantibody to alternate pathway C3 convertase, was present. Low serum complement C3 and C5 levels were also noted. The depressed complement levels, in conjuction with terminal complement complexes at the upper limit of normal, suggest activation of the early and late complement cascade. We suggest that children presenting with meningococcal infection should have a regular urine examination, as well as full complement measurements performed, in view of the association with hypocomplementaemic mesangiocapillary glomerulonephritis. Similarly, prophylactic penicillin should be prescribed for patients with mesangiocapillary glomerulonephritis and persistently low C5 levels to prevent meningococcal complications. |
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| Keywords: | Mesangiocapillary glomerulonephritis Meningococcal meningitis Complement C3 and C5 C3-nephritic factor |
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