SARS动物模型研究进展

自从2003年SAILS暴发以来，SAILS动物模型的制备有了很大的进展，几种动物模型包括非人灵长类、小鼠、仓鼠、狸子猫和雪貂等都能支持SAILS-CoV的复制，其中有些动物显示了不同程度的病理变化。然而现有的SARS动物模型由于缺乏与SARS患者一致的临床疾病和病理变化，还不十分令人满意。由于动物模型在SARS研究的整个过程中发挥很重要的作用，因此有必要继续研究更为敏感的SARS动物模型。

Update on the Animal Models for SARS

Objective Since the outbreak of severe acute respiratory syndrome(SARS) in 2003,rapid progresses have been made in the development of SARS animal models.Several animal models including nonhuman primates,mice,hamster,civet and ferret all support SARS-CoV replication and some of them show pathological changes with different severity.However,present alternatives are not fully satisfied by absence of consistent clinical illness and pathological changes observed in humans with SARS.Because animal models play important roles in the entire process of SARS research,it is necessary to continuously develop more susceptible animal models for SARS.