In vitro evaluation,biodistribution in rats of radiolabeled raloxifene |
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| Authors: | Elif Bayrak Fatma Yurt Lambrecht Kubra Durkan Osman Yilmaz |
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| Affiliation: | 1. Molecular Tumor Biology, Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany;2. Molecular Psychopharmacology, Department of Psychiatry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany;3. Experimental Ophthalmology, Dept. of Ophthalmology, University of Mainz, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany |
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| Abstract: | Raloxifene is a selective estrogen receptor modulator that produces both estrogen agonistic effects on bone and lipid metabolism and estrogen-antagonistic effects on uterine endometrium and breast tissue.In the present study, raloxifene was labeled with I-131 by iodogen method and investigated for its radiopharmaceutical potential. Radiolabeling yield is 91±0.7%, as determined by radio thin layer chromatography (RTLC). Results of in vitro study indicated 131I-raloxifene has high stability (4 h) in serum. Biodistribution study was carried out with Albino wistar female rats. The result has shown that the radioiodinated raloxifene has higher uptake in uterus than breast and ovarian. |
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