Effect of curcumin on brain insulin receptors and memory functions in STZ (ICV) induced dementia model of rat |
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| Authors: | Rahul Agrawal Bhanvi Mishra Ethika Tyagi Chandishwar Nath Rakesh Shukla |
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| Institution: | 1. Department of Physiology, Shandong University, School of Medicine, Wenhuaxilu Road, Jinan, Shandong Province 250012, PR China;2. Key Laboratory of Medical Neurology of Shandong University, School of Medicine, Wenhuaxilu Road, Jinan, Shandong Province 250012, PR China;3. Department of Physiology, Shandong Medical College, Nanwaihua Road, Jinan, Shandong Province 250012, PR China;4. Neurosurgery Department, Qilu Hospital, Shandong University, Wenhuaxilu Road, Jinan, Shandong Province, 250012, PR China;1. China-Japan Research Institute of Medical and Pharmaceutical Sciences, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, China;2. Department of Chemistry and Life Science, School of Advanced Engineering Kogakuin University, 2665-1, Nakanomachi Hachioji, Tokyo, 192-0015, Japan;3. Nippi Research Institute of Biomatrix, Toride, Ibaraki 302-0017, Japan;4. Medical Research Institute of Curing Mibyo, 1-6-28, Narusedai, Machida, Tokyo, 194-0042, Japan;5. Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Shenyang 110016, China |
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| Abstract: | Curcumin, the principal curcuminoid of turmeric, exhibits beneficial role in several neurodegenerative disorders such as dementia of Alzheimer type. Recent evidences suggest the involvement of brain insulin receptors (IRs) in the pathophysiology of dementia disorders. Therefore, the present study was undertaken to investigate the effect of curcumin on memory functions, brain IRs, acetylcholinesterase (AChE) activity and oxidative stress in intracerebroventricular (ICV) administered streptozotocin (STZ) induced dementia in rats. Rats were injected with STZ (3 mg/kg, ICV) bilaterally twice, on day 1 and 3 and curcumin (200 mg/kg, po) was administered in pre- and post-treatment schedules. STZ (ICV) treated group had shown memory deficit as indicated by no significant decrease in latency time in Morris water maze test and significant decrease in IR protein level in both hippocampus and cerebral cortex. Pre- and post-treatment of curcumin in STZ (ICV) treated rats significantly restored the memory deficit and IR protein level in both the regions. Furthermore, STZ (ICV) resulted into enhanced AChE activity in hippocampus and cerebral cortex which was normalized by curcumin pre- and post-treatment. An increase in MDA level and decrease in GSH level were obtained in both hippocampus and cerebral cortex in STZ treated group, indicating state of oxidative stress, which was also attenuated by pre- and post-treatment of curcumin. The results suggest that besides the anticholinesterase and antioxidant activity, effect on brain IR may also be an important factor for protective effect of curcumin against STZ induced dementia model. |
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