A simple method for the quality control of [18F]FDG |
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| Authors: | J. Koziorowski |
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| Affiliation: | 1. Division of Nuclear Medicine, Department of Radiology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA;2. The Interdepartmental Program in Medicinal Chemistry, The University of Michigan, Ann Arbor, MI 48109, USA;1. Department of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA;2. ABT Molecular Imaging, 3024 Topside Business Park Drive, Louisville, TN 37777, USA;1. National Almazov Medical Research Centre, PET Centre, 2 Akkuratova street, 197341, St. Petersburg, Russia;2. N.P. Bechtereva Institute of Human Brain, Russian Academy of Science, Laboratory of Radiochemisty, 9 Ak. Pavlova st., 197376, St. Petersburg, Russia;3. St.-Petersburg State University, Institute of Chemistry, Universitetskaya Emb., 13B, 199034, St. Petersburg, Russia;1. Verein für Kernverfahrenstechnik und Analytik Rossendorf e.V. (VKTA), P.O. Box 510119, D-01314 Dresden, Germany;2. Helmholtz-Zentrum Dresden-Rossendorf (HZDR), P.O. Box 510119, D-01314 Dresden, Germany;1. Department of Nuclear Medicine, University Hospital Würzburg, 97080 Würzburg, Germany |
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| Abstract: | Most automated synthesis modules produce [18F]FDG within half an hour, but the quality control involving up to three separate methods and three different analytical systems is time consuming. The use of HPLC, TLC, and GC for the quality control of [18F]FDG is both time consuming and expensive (high purchase costs). Presented here is a method using a single HPLC system for all three analyses. |
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