XELOX方案联合华蟾素胶囊治疗晚期结直肠癌的临床效果及安全性

目的 观察XELOX方案联合华蟾素胶囊治疗晚期结直肠癌(CRC)的临床效果及安全性.方法 将62例晚期CRC患者随机分为对照组与治疗组,各31例.对照组单纯给予XELOX(卡培他滨+奥沙利铂)化疗方案,治疗组在对照组基础上给予华蟾素胶囊治疗.采用RECIST 1.1疗效评价系统比较两组临床疗效;比较两组治疗前、后CA1...

Clinical effect and safety of XELOX regimen combined with Huachansu capsule in the treatment of advanced colorectal cancer

Objective To observe the clinical effect and safety of XELOX regimen combined with Huachansu capsule in the treatment of advanced colorectal cancer(CRC).Methods A total of 62 patients with advanced CRC were randomly divided into control group and treatment group,with 31 cases in each group.The control group was given XELOX(capecitabine+oxaliplatin)chemotherapy regimen alone,and the treatment group was treated with Huachansu capsule on the basis of the control group.RECIST 1.1 efficacy evaluation system was used to compare the clinical efficacy of the two groups;the CA199 and CEA levels before and after treatment were compared between the two groups;the adverse reactions of the two groups were graded and evaluated according to CTCAE v 4.0;the VAS score was used to compare the pain relief degree of the two groups,and the KPS score was used to compare the functional improvement degree of the two groups.Results The ORR of the treatment group was 67.74%,which was significantly higher than 41.94%of the control group(P<0.05).After treatment,the serum CEA and CA199 levels of the two groups significantly reduced,and those of the treatment group were lower than the control group(P<0.05).The total incidences of gradeⅠ-Ⅳgastrointestinal reaction,bone marrow suppression,liver function damage and peripheral nerve damage in the treatment group were lower than those in the control group(P<0.05).After treatment,the VAS score of the two groups decreased significantly,and the KPS score increased significantly,and those of the treatment group were better than the control group(P<0.05).Conclusion XELOX regimen combined with Huachansu capsule has a clear clinical effect in the treatment of advanced CRC,it can reduce the incidece of toxic and side effects,improve the safety of treatment,and which is worthy of clinical promotion.