Therapy-related chromosomal changes and cytogenetic heterogeneity in human gliomas |
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Authors: | Li You S Ramsay David A Macdonald/snm> David R Del Maestro Rolando F |
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Institution: | (1) Department of Pathology, Canada;(2) London Regional Cancer Centre, London, Ontario, Canada;(3) Division of Neurosurgery, Canada |
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Abstract: | The karyotypes of 18 primary untreated gliomas, 6 recurrent gliomas treated with radiotherapy and/or chemotherapy and 2 gliomas before and after treatment are described, based on observations using standard cytogenetic techniques. In comparison to the untreated gliomas there were relatively consistent chromosome differences in the treated gliomas, including (1) deletions ofthe long arm of chromosome 7 with breakpoint at q22, possibly induced by alkylating agents, and (2) numerous single cell abnormalities or unrelated clones of structural abnormalities, presumably induced by radiotherapy. |
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Keywords: | chemotherapy adjuvant chromosome abnormalities chromosomal heterogeneity iatrogenic disease glioma radiotherapy |
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