利培酮治疗精神分裂症疗效的纵向观察

目的 探讨利培酮对精神分裂症的维持治疗效果、维持剂量及其安全性，并进行初步的社会经济学分析。方法 对使用利培酮与氯氮平治疗的两组患进行三年观察，比较其疗效、副反应、依从性及社会经济学方面的差异。结果 利培酮组疗效与氯氮平组相似，但副反应少，治疗依从性好，复发及脱落率低，社会功能恢复较好，社会经济学比较无明显差异。结论 利培酮为一有效、安全的维持治疗用药，且并不增加患的经济负担。

Longitudinal observation of risperidone in the treatment of schizophrenics

Objective To investigate the maintenance efficacy, dosage and safety of risperidone in schizophrenia and make initial social - economic analysis. Methods Two groups of patients respectively treated by risperidone or clozapine were followed up for three years. The differences of curative effects, side effects, compliance and social - economic aspects were compared between the 2 groups. Results There was no difference in curative effects and social - economic aspects . But risperidone has less side effects, better compliance, lower relapse and scaling rates than clozapine group does. Conclusion Resperidone is an effective, safe and economical maintenance treating drug.