脑低灌注患者检测血浆β淀粉样蛋白1-40和1-42水平的价值

目的探讨脑低灌注(CHP)患者血浆中β淀粉样蛋白1-40(Aβ1-40)和Aβ1-42测定的临床价值。方法以ELISA法,检测44例经CT血管成像确定狭窄程度<70%的脑低灌注患者和40例同期对照(HC)者的血浆Aβ1-40和Aβ1-42水平。结果 CHP组血浆Aβ1-40和Aβ1-40/Aβ1-42比值明显高于HC组,而Aβ1-42水平则明显低于HC组。Aβ1-40和Aβ1-42是与血管狭窄相关的独立因素(R2=0.923,P<0.01)。结论脑缺血损伤导致CHP患者血浆Aβ1-40升高和Aβ1-42降低,对其进行检测具有一定的临床诊断价值。

Evaluation of determination of plasma amyloid beta protein 1-40 and 1-42 in patients with cerebral hypoperfusion

Objective It is to measure the level of beta-amyloid protein(1-40) and(1-42)(Aβ1-40,Aβ1-42) in patients with cerebral hypoperfusion(CHP) and to explore its clinical value.Methods The plasma levels of Aβ1-40 and Aβ1-42 of 44 cases with a cerebral stenosis degree less than 70% diagnosed by CT angiography and 40 health controls(HC) were measured by ELISA assay.Results The level of plasma Aβ1-40 and ratio of Aβ1-40/Aβ1-42 in CHP patients were significantly higher than that in HC objectives,while the Aβ1-42 acts the versa(P<0.01).The plasma Aβ1-40 and Aβ1-42 were independent factors related to vascular stenosis degree(R2=0.923,P<0.01).Conclusion The increase of plasma Aβ1-40 and decrease of Aβ1-42 can be results from cerebral ischemic insults,which can be detected possessing considerable values for clinical diagnosis.