| 姜黄素及BMSCs对溃疡性结肠炎小鼠肠黏膜病理改变的影响 |
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| 引用本文： | 刘冬冬,王营. 姜黄素及BMSCs对溃疡性结肠炎小鼠肠黏膜病理改变的影响[J]. 现代中西医结合杂志, 2011, 20(33): 4200-4202 |
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| 作者姓名： | 刘冬冬 王营 |
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| 作者单位： | 1. 徐州医学院,江苏,徐州,221002
2. 徐州医学院附属医院,江苏,徐州,221002 |
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| 摘 要： | 目的观察姜黄素及骨髓间充质干细胞(BMSCs)对溃疡性结肠炎(UC)小鼠结肠黏膜病理变化的影响。方法用2,4,6-三硝基苯磺酸(TNBS)灌肠制造溃疡性结肠炎小鼠模型,观察姜黄素联合BMSCs对小鼠行为及体质量变化、结肠黏膜大体形态和组织病理学评分的影响。结果造模组小鼠经治疗,行为改变及体质量变化小,肠黏膜大体形态评分、组织学评分降低,与模型组比较均有显著性差异(P均<0.05)。结论姜黄素联合BMSCs能有效减轻溃疡性结肠炎小鼠结肠黏膜的病变损伤,促进肠黏膜的修复。
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| 关 键 词： | 姜黄素 骨髓间充质干细胞 溃疡性结肠炎 |
Influence of curcumin and BMSCs on pathological changes of colonic mucous in mice with ulcerative colitis |
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| Liu Dongdong,Wang Ying. Influence of curcumin and BMSCs on pathological changes of colonic mucous in mice with ulcerative colitis[J]. Modern Journal of Integrated Chinese Traditional and Western Medicine, 2011, 20(33): 4200-4202 |
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| Authors: | Liu Dongdong Wang Ying |
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| Affiliation: | Liu Dongdong1,Wang Ying2 (1.Xuzhou Medical College,Xuzhou 221002,Jiangsu China,2.The Affiliated Hospital of Xuzhou Medical College,Jiangsu,China) |
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| Abstract: | Objective It is to observe the influence of curcumin and bone marrow mesenchymal stem cell(BMSCs) on the pathological changes of colonic mucous in mice with ulcerative colitis(UC). Methods Mouse animal model of ulcerative colitis was established by trinitrobenzene sulphonic acid(TNBS) enema.The influence of BMSCs and curcumin on behavior,weight,macroscopical and histological were observed. Results In treatment group,after treatment,the changes of behavior and body weight of mice were slight,and the scores o... |
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| Keywords: | curcumin bone marrow mesenchymal stem cells ulcerative colitis |
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