| LMP2与LMP7基因多态性与强直性脊柱炎并发虹睫炎易感性关系的研究 |
| |
| 引用本文： | 丁海明,吕厚山,陈占昆.LMP2与LMP7基因多态性与强直性脊柱炎并发虹睫炎易感性关系的研究[J].中华风湿病学杂志,1999,3(2). |
| |
| 作者姓名： | 丁海明 吕厚山 陈占昆 |
| |
| 作者单位： | 北京医科大学人民医院关节病诊疗研究中心 |
| |
| 摘 要： | 目的研究ＬＭＰ基因多态性与强直性脊柱炎并发虹睫炎发病的关系。方法应用ＰＣＲ对正常人和病人进行ＨＬＡＢ２７检测以及ＬＭＰ２和ＬＭＰ７扩增。ＣｆｏＩ进行限制性酶切图谱分析。结果强直性脊柱炎有虹睫炎（ＡＳ＋ＡＡＵ）病史以及单纯虹睫炎（ＡＡＵ）患者ＬＭＰ２基因ＢＢ纯合型较正常人以及强直性脊柱炎（ＡＳ）患者明显增高（Ｐ＜００５），ＡＳ＋ＡＡＵ患者ＢＢ型ＯＲ＝３６，ＡＡＵ患者ＢＢ型ＯＲ＝５８３。ＬＭＰ７基因多态性无明显差别。结论在我国汉人中，ＬＭＰ２基因多态性与ＡＳ＋ＡＡＵ以及ＡＡＵ发病存在明显相关关系。
|
| 关 键 词： | LMP基因 多态现象 脊柱炎.强直性 虹膜睫状体炎 |
Association of the polymorphism of LMP2 and LMP7 genes with the susceptibility to acute
anterior uveitis in patients with ankylosing spondylitis |
| |
| DING Haiming,L Houshan,CHEN
Zhankun,et al..Association of the polymorphism of LMP2 and LMP7 genes with the susceptibility to acute
anterior uveitis in patients with ankylosing spondylitis[J].Chinese Journal of Rheumatology,1999,3(2). |
| |
| Authors: | DING Haiming L Houshan CHEN
Zhankun |
| |
| Institution: | DING Haiming,L Houshan,CHEN
Zhankun,et al.Peoples Hospital,Beijing Medical University,Beijing,100044 |
| |
| Abstract: | Objective
To evaluate the polymorphism of LMP2 and LMP7 genes in patients with ankylosing spondylitis
(AS) and /or acute anterior uveitis (AAU). Methods HLAB27 typing was performed and LMP2 and
LMP7 amplified fragment length polymorphisms were determined after PCR and digestion with
CfoI restriction enzyme. Results There was a significantly increased LMP2BB genotypic
frequency in patients with AS+AAU (857%) and AAU (87%) when compared with controls (533%)
and AS patients (625%) (P<005),but no difference in LMP7 genotype.Odds ratio (OR) relating
LMP2 BB and AAU was 583 and OR for AS+AAU was 36. Conclusion The polymorphism of LMP2
gene is strongly associated with the development of AAU in AS patients and uncomplicated AAU
patients. |
| |
| Keywords: | LMP genepolymorphismspondylitis ankylosingiridocyclitis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
