|
|||||
|
|
The expression of Midkine gene in patients with acute myeloid leukemia and its significance |
|
| Authors: | Amira A. Hammam Dina H. El Dahshan Hassan M. Metwally Mohamed A. El Feky |
| Affiliation: | 1. Department of Clinical Pathology, Beni Suef University, Beni Suef, Egypt 2. Department of Oncology, Menofia University, Shibin El Kom, Menofia Governorate, Egypt 3. Department of Internal Medicine, Beni Suef University, Beni Suef, Egypt |
| Abstract: | Midkine (MK) is a heparin-binding growth factor and a product of a retinoic acid-responsive gene. Midkine is overexpressed in many carcinomas and thought to play an important role in carcinogenesis. However, no studies have been focused on the role of MK in AML. This study sought to evaluate the expression of MK among AML patients to explore possible correlation between MK expression and different clinicopathologic variables in an attempt to determine the prognostic value of MK expression. Mononuclear cells were separated from samples of 50 newly diagnosed cases of AML; 10 healthy volunteers were included in this study as control group. The reverse transcription polymerase chain reaction method was used to examine the expression of MK mRNA in mononuclear cells. Midkine gene mRNA expression rate was significantly higher in AML patients when compared to control group (p?p?>?0.05). Moreover, Midkine expression was significantly higher in patients that did not achieve complete remission compared to those who succeeded to achieve one (p? |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |