| 花椒油素对血小板粘附和丙二醛生成的影响 |
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| 引用本文： | 金云海,林继红,程远远. 花椒油素对血小板粘附和丙二醛生成的影响[J]. 南方医科大学学报, 2000, 20(1): 39-40 |
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| 作者姓名： | 金云海 林继红 程远远 |
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| 作者单位： | 1. 第一军医大学药理教研室,广东,广州,510515
2. 暨南大学医学院附属医院药剂科,广东,广州510630 |
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| 摘 要： | 目的观察花椒油素（Ｘａｎｔｈｏｘｙｌｉｎ）对血小板粘附和丙二醛产生的影响。方法用转动圆瓶法和２－硫代巴比妥酸（ＴＤＡ）荧光微测定法研究花椒油素对大鼠血小板粘附和丙二醛（ＭＤＡ）生成的影响。结果体外实验： ＸＴ ０．０３７， ０．１８５， ０．９２４， ９．２４０ μｍｏｌ／Ｌ显著抑制血小板粘附和ＭＤＡ的产生，血小板粘附的抑制率为４９．９％－８７．１％，ＭＤＡ产生的抑制率为２３．２～４６．４％；体内实验：５ｍｇ／ｋｇ ＸＴ也显著抑制血小板粘附和ＭＤＡ的产生，血小板粘附的抑制率为５６．８％，ＭＤＡ产生的抑制率为４１．５％。结论体外实验血小板粘附的抑制率和ＭＤＡ产生的抑制率间呈非常显著的线性正相关。
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| 关 键 词： | 花椒油素(XT) 血小板粘附 丙二醛(MDA) 2-硫代巴比妥酸(TBA) 1 1 3 3-四乙氧基丙烷(TEP)荧光微测定法 |
Effects of xanthoxylin on platelet adhesion and malondialdhehyde production in rats |
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| JIN Yun-hai,LIN Ji-hong,CHENG Yuan-yuan. Effects of xanthoxylin on platelet adhesion and malondialdhehyde production in rats[J]. Journal of Southern Medical University, 2000, 20(1): 39-40 |
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| Authors: | JIN Yun-hai LIN Ji-hong CHENG Yuan-yuan |
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| Affiliation: | JIN Yun-hai,LIN Ji-hong,CHENG Yuan-yuan Department of Pharmacology,First Military Medical University,Guangzhou 510515,China,Department of Pharmacy,Affiliated Hospital of Medical College,Ji'nan University,Guangzhou 510630,China |
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| Abstract: | Objective To study the effects of xanthoxylin on platelet adhesion and malondialdhehyde(MDA) production in rats. Methods Revolving round bottle and 2-thiobarbituric acid (TBA) fluorescence micro-determination were used. Results in the in vitro experiment, xanthoxylin significantly inhibited platelet adhesion and MDA production, and the inhibitory rate of the former was 49.9% 87. 1 %, and tile latter was 23.2% 146.4%. In the vivo experiment, it significantly inhibited platelet adhesion and MDA production as well when xanthoxylin 5mg/kg was administered orally,and the inhibitory rate of platelet adhesion was 56.8% and that of MDA production was 41.5%. Conclusion it was suggested that in the in vitro experiment. there is a positive correlation between inhibitory rate of platelet adhesion and that of MDA production. |
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| Keywords: | xanthoxylin platelet adhesion malondialdhehyde(MDA) 2-thiobarbituric acid(TBA) 1 1 3 3-tetraethoxypropane (TAP)fluorescence micro- determination |
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