| 复方氨酚那敏缓释片释放度测定方法及其体外释药动力学研究 |
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| 引用本文： | 杨金荣,朱彧,王润玲,李雅静,张庆伟,赖作刚,张一兰.复方氨酚那敏缓释片释放度测定方法及其体外释药动力学研究[J].中国药学杂志,2008,43(3):222-224. |
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| 作者姓名： | 杨金荣 朱彧 王润玲 李雅静 张庆伟 赖作刚 张一兰 |
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| 作者单位： | 1. 天津医科大学药学院,天津,300070
2. 天津市太平洋制药有限公司,天津,300381 |
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| 摘 要： | 目的建立复方氨酚那敏缓释片释放度测定方法,并评价其体外释药特性。方法进行体外释放度实验,考察释放介质对释放度的影响。结果复方氨酚那敏缓释片具有明显的缓释作用,3种主成分的体外释放均符合一级动力学规律。结论该缓释片处方合理,达到了预期结果。
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| 关 键 词： | 对乙酰氨基酚 咖啡因 马来酸氯苯那敏 缓释片 释放度 |
| 文章编号： | 1001-2494（2008）03-0222-04 |
| 收稿时间： | 2007-01-15 |
| 修稿时间： | 2007年1月15日 |
Study on Determination of Release of Fufang Anfen Namin Sustained-Release Tablets in Vitro |
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| YANG Jin-rong,ZHU Yu,WANG Run-ling,LI Ya-jing,ZHANG Qing-wei,LAI Zuo-gang,ZHANG Yi-lan.Study on Determination of Release of Fufang Anfen Namin Sustained-Release Tablets in Vitro[J].Chinese Pharmaceutical Journal,2008,43(3):222-224. |
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| Authors: | YANG Jin-rong ZHU Yu WANG Run-ling LI Ya-jing ZHANG Qing-wei LAI Zuo-gang ZHANG Yi-lan |
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| Institution: | 1.College of Pharmacy，Tianjin Medical University，Tianjin 300070，China； 2.Tianjin Pacific Pharmaceutical Co．Ltd，Tianjin 300381，China |
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| Abstract: | OBJECTIVE To study the determination of release rate of Fufang Anfen Namin, and evaluate the drug release property. METHODS Experiment of release rate in vitro was carried on and medium effects upon the release were investigated. RESULTS The tablets had a sustained-release profile. The release pattern of the main composition all followed the first order kinetics. CONCLUSION With the reasonable formulation, the sustained-release tablets reach the expected level. |
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| Keywords: | acetaminophen caffeine chlorpheniramine maleate sustained-release tablets release rate |
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