Genetic markers in primary open-angle glaucoma |
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Authors: | Emilio Abecia Begoña Martínez-Jarreta Yolanda Casalod Blanca Bell Isabel Pinilla Francisco M Honrubia |
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Institution: | (1) Department of Ophthalmology, Miguel Servet Hospital, Zaragoza, Spain;(2) Department of Legal Medicine, University of Zaragoza, Spain |
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Abstract: | Purpose: To investigate possible associations between genetic markers and Primary Open-Angle Glaucoma (POAG). Methods: A number of genetic markers were typed in 84 unrelated patients with POAG and compared with a random sample of healthy individuals. The markers were Transferrin, Group Specific Component, G1m (1), G1m (2) and G3m (5) Allotypes, Adenylate Kinase, Adenosin Deaminase, Glyoxalase I and Acid Phosphatase and PCR-based markers HLA-DQA1 and D1S80. Results: No significant differences were found except the strong association between the group of POAG patients and Acid Phosphatase ACP*C allele ( 2 = 32.86; p < 0.0001). Conclusions: Since Acid Phosphatase gene is localized to chromosome 2p23, this result could be a first comprehensive step in the localization of POAG genes. |
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Keywords: | genetics glaucoma genetic markers polymorphisms POAG |
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