肝硬化患者血清胆碱酯酶检测的临床意义分析

【目的】探讨血清胆碱酯酶检测对诊断肝硬化的临床意义。【方法】选择2005年6月至2007年8月在本院住院治疗的90例肝硬化患者，同时选择90例健康体检者作为对照，清晨空腹采集静脉血测定血清胆碱酯酶活性和白蛋白水平，并作组间比较。【结果】肝硬化组90例患者平均血清胆碱酯酶水平和白蛋白水平分别为（2321±845）U／L和（31．2±6．3）g／L，而健康对照组平均水平为（8726±911）U／L和（44．6±2．8）g／L，肝硬化患者血清胆碱酯酶水平较对照组显著降低（P〈0．05）；Chitd A、B、C三级患者血清胆碱酯酶活性和白蛋白均明显下降，各级之间差异有显著性（P〈0．05），下降程度为ChildC级〉ChildB级〉ChildA级，血清胆碱酯酶水平和白蛋白水平与肝硬化Child-Pugh分级呈负相关。【结论】临床上可通过检测血清胆碱酯酶活性来了解肝组织受损的程度，以协助判断肝硬化发展的严重程度及预后。

Clinical Value of Serum Cholinesterase Detection in Patients with Hepatic Cirrhosis

Objective] To explore the clinical value of serum cholinesterase detection in patients with hepatic cirrhosis. Methods] Ninety hepatic cirrhosis patients in our hospital from June 2005 to August 2007 and 90 healthy individuals as controls were selected. The fasting venous blood in morning was collected to detect serum cholinesterase and albumin. These two groups were compared. Results] The average levels of cholinesterase levels and albumin in hepatic cirrhosis group were （2321±845）U/L and （31.2±6.3）g/L, respectively, while those in the control group were （8726±911）U/L and （44.6±2.8）g/L, respectively, and the difference was statistically significant（ P 〈0.05）. The levels of cholinesterase and albumin in patients with Child A, B and C were obviously decreased, and the differences were statistically significant （ P 〈0.05）. The decreasing degree was ChildC 〉ChildB〉ChildA,. and the levels of cholinesterase and albumin were negatively correlated to the grade of hepatic cirrhosis. Conclusion]The levels of serum cholinesterase and albumin are favorable to identify the degree of injury of liver tissue, which are helpful to judge the severity of development and prognosis of hepatic cirrhosis.