Cerebrospinal fluid levels of interleukin-6 and interleukin-12 in children with meningitis |
| |
Authors: | Chia-Chang Hsieh Jen-Her Lu Shu-Jen Chen Cheng-Chou Lan Wen-Chi Chow Ren-Bin Tang |
| |
Institution: | (1) Department of Pediatrics, Taipei Veterans General Hospital, 201, Sec. 2, Shih-Pai Road, Taipei, Taiwan, Republic of China;(2) National Yang-Ming University, Taipei, Taiwan, Republic of China |
| |
Abstract: | Purpose Certain cytokines play important roles in the pathophysiology of meningitis. The main purpose of this study was to investigate
if the levels of interleukin-6 (IL-6) and interleukin-12 (IL-12) in cerebrospinal fluid (CSF) could be diagnostic predictors
of bacterial meningitis in children.
Methods CSF was obtained from 95 patients suspected with meningitis. These cases were classified to the bacterial meningitis (n = 12), aseptic meningitis (n = 41), and nonmeningitis (n = 42) groups. The levels of IL-6 and IL-12 in CSF were measured using the enzyme-linked immmunosorbent assays test.
Results The CSF IL-6 levels in the bacterial meningitis group (45.2 ± 50.0 pg/ml) were significantly higher than those in the aseptic
meningitis group (12.9 ± 10.2 pg/ml) and the nonmeningitis group (6.5 ± 7.8 pg/ml; p < 0.05). The CSF IL-12 levels in the bacterial meningitis group (69.8 ± 67.1 pg/ml) were significantly higher than those
in the aseptic meningitis group (22.9 ± 10.8 pg/ml) and the nonmeningitis group (15.3 ± 11.2 pg/ml; p < 0.05). With regard to diagnosis, the measurement of CSF IL-6 and IL-12 levels showed sensitivities of 96% and 96%, respectively,
and specificities of 51% and 75%, respectively.
Conclusion It is suggested that the CSF IL-6 and IL-12 levels are useful markers for distinguishing bacterial meningitis from aseptic
meningitis. |
| |
Keywords: | Aseptic meningitis Bacterial meningitis Interleukin-6 Interleukin-12 |
本文献已被 PubMed SpringerLink 等数据库收录! |
|