老年男性雄激素水平与冠状动脉粥样硬化病变程度的相关性分析

目的:探讨老年男性雄激素水平与冠状动脉粥样硬化病变程度之间的关系。方法:选择住院并接受冠状动脉造影检查的老年男性患者,并根据冠脉造影结果分为冠脉正常组(对照组)、单支病变组(SV group)、双支病变组(DV group)、三支病变组(TV group),每组32例,共128例。于入院24 h内空腹抽血,测总睾酮(TT)及性激素结合蛋白(SHBG)值,并根据Vermeulen公式计算游离睾酮(FT)。比较各组间TT、FT的差异,并分析TT及FT与冠脉病变程度的相关性。结果:FT在各组间存在显著差异(P<0.05或P<0.01),在冠心病各组中均低于正常对照组,且与冠脉病变程度呈负相关。虽然病变组与对照组的TT存在统计学差异(P<0.05),但是各病变组之间TT则无统计学差异(P>0.05)。结论:FT比TT更能反映冠脉病变程度,其水平越低提示冠脉病变越严重。

Relationship between androgen levels and pathological changes of coronary atherosclerosis in elderly males

Objective: To explore the relationship between androgen levels and pathological changes of coronary artery in elderly males.Methods: One hundred and twenty-eight in-patients who received coronary angiography were divided into four groups:single vessel lesion group(SV group),double vessel lesion group(DV group),three vessel lesion group(TV group) and control group.The levels of serum total testosterone(TT) and sex hormone binding globulin(SHBG)were assayed by ELISA,and free testosterone(FT) calculated with the Vermeulen formula.Results: There was significant difference in FT levels among these four groups,while there was no statistical difference in TT levels.FT level in TV group was lower than that in DV group and SV group.Conclusion: Serum levels of free testosterone may be correlated with pathological degree of coronary artery.