Neurotensin neurons in the ventral tegmental area project to the medial nucleus accumbens |
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Authors: | Peter W. Kalivas Jane S. Miller |
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Affiliation: | Department of Biochemical Pharmacology, Janssen Pharmaceutica, B-2340 Beerse Belgium |
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Abstract: | Opiate receptors measured in vitro or in vivo with [3H]lofentanil in the rat vagus nerve were found to accumulate on both sides of a ligature, thus indicating a bidirectional axoplasmic transport of these receptors. When rats were treated with capsaicin, the accumulation of opiate receptors was tremendously reduced in the vagus whereas muscarinic receptors in ligated sciatic nerves were unaffected. Since capsaicin is known to affect sensory neurones, mostly those containing substance P, the present results support the idea that the opiate receptors in the vagus are associated with substance P neurones. |
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Keywords: | neurotensin ventral tegmental area dopamine horseradish peroxidase immunohistochemistry nucleus accumbens diagonal band of Broca |
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