帕瑞昔布复合地佐辛用于下肢骨折急性疼痛的疗效观察

目的探讨帕瑞昔布复合地佐辛用于下肢骨折急性疼痛的临床效果。方法 ASA I~II下肢骨折患者50例,随机分为两组,帕瑞昔布+地佐辛(PD)组和咪达唑伦(M)组,观察记录入室时(T1)、用药后10min后(T2)、体位变动时(T3)的MAP、HR、SpO2,并在各时点进行疼痛视觉模拟评分法(VAS)评估患者疼痛程度。结果在T2、T3时间点中M组MAP、HR、VAS评分较PD组明显升高(P<0.05);在T1时间点两组间MAP、HR、VAS差异无统计学意义(P>0.05);各时间点两组间SpO2差异无统计学意义(P>0.05)。结论帕瑞昔布复合地佐辛能有效减轻下肢骨折患者引起的急性疼痛,而且临床安全性高。

Effect of Parecoxib Combine Decocine on Acute Pain During Fracture of Lower Limb

Objective To investigate the clinical effect of parecoxib composite decocine on acute pain during fracture of lower limb. Methods 50 ASA Ⅰ-Ⅱ patients undergoing fracture fixation operation of lower limb with combined spinal-epidural anesthesia were randomly divided into 2 groups： parecoxib composite deeocine group （PD） and midazolam group （M） . MAP, HR, SpO2 of all patients were observed at entering operating room （TI） , at 10minutes after dosage （T2） , at posture changing （T3） , and Visual Analogue Scale （VAS） were performed to all patients at above set point. Results MAP, HR, VAS showed significant difference between M group and PD group, M group was higher than PD group at T2, T3 （P〈0.05） . MAP, HR, VAS had no difference between M group and PD group at T1 （P〉0.05） . SpO2 was no difference between M group and PD group at all set piont （P〉0.05） . Conclusion Parecoxib composite decocine may relieved acute pain from fracture of lower limb, and the clinical safty is high.