A placebo-controlled,cross-over trial of lamotrigine in depersonalization disorder |
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Authors: | Sierra Mauricio Phillips Mary L Ivin Glynis Krystal John David Anthony S |
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Institution: | Institute of Psychiatry, Department of Psychological Medicine, Kings College, London University, London UK. m.sierra-siegert@iop.kcl.ac.uk |
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Abstract: | There is evidence to support the view that glutamate hyperactivity might be relevant to the neurobiology of depersonalization. We tested the efficacy of lamotrigine, which reduces glutamate release, as a treatment for patients with depersonalization disorder. A double-blind, placebo-controlled, cross-over design was used to evaluate 12 weeks of treatment of lamotrigine. Subjects comprised nine patients with DSM-IV depersonalization disorder. Changes on the Cambridge Depersonalization Scale and the Present State Examination depersonalization/derealization items were compared across the two cross-over periods. Lamotrigine was not significantly superior to placebo. None of the nine patients was deemed a responder to the lamotrigine arm of the cross-over. Lamotrigine does not seem to be useful as a sole medication in the treatment of depersonalization disorder. |
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