中国汉族人群白介素-1α-889C/T多态性与阿尔茨海默病的相关性

目的研究中国汉族人群白介素1α-889C/T(IL-1α-889C/T)多态性与阿尔茨海默病(AD)发病的相关性。方法通过实时定量荧光聚合酶链反应检测520例AD患者和505例非痴呆对照者IL-1α-889C/T的基因多态性,应用logistic回归模型和χ2检验分析IL-1α-889C/T基因多态性与AD发病的相关性。结果在AD组中IL-1α-889C/C、C/T和T/T基因型频率分别为70·96%、25·77%和3·27%,在对照组中分别为80·59%、18·22%和1·19%;携带T/T和C/T基因型的个体比携带C/C基因型个体显示出较高的AD发病危险性(OR值分别为3·13和1·61,P<0·05);非条件logistic回归分析提示IL-1α-889C/T和T/T基因型、高龄(≥65岁)和女性是AD发病的危险性因素,调整年龄和性别的影响后,IL-1α-889C/T和T/T基因型仍与AD的发病存在相关性(OR=1·74,95%CI1·25~2·43,P=0·001;OR=3·57,95%CI1·23~10·37,P=0·019)。结论IL-1α-889基因多态性与AD易患性有关,其中IL-1α-889C/T和T/T基因型、高龄和女性是AD发病的危险性因素,共同影响AD的发病。

Association between interleukin-1 alpha-889 C/T polymorphism and Alzheimer's disease in Chinese Han population

OBJECTIVE: To explore the possible association between interleukin-1 alpha-889C/T (IL-1 alpha-889 C/T) polymorphism and Alzheimer's disease (AD) in Chinese Han population. METHODS: A total of 520 AD patients and 505 normal controls were enrolled. The polymorphism of IL-1 alpha-889C/T was detected with real-time polymerase chain reaction. Multiple logistic regression and chi square test were performed for statistical analysis. RESULTS: The frequencies of C/C, C/T, and T/T genotypes were 70.96%, 25.77%, and 3.27%, respectively, among AD patients, and 80.59%, 18.22%, and 1.19%, respectively, among non-dementia controls. In multivariate analysis, T/T and C/T genotypes of IL-1 alpha-889, age > or =65 years, and female were risk factors for AD. Adjusted for the age and sex, T/T and C/T genotypes were still associated with AD. The odds ratio for AD were 3.57 and 1.74 for individuals with T/T and C/T genotypes compared with individuals with C/C genotype. P value was 0. 019 and 0. 001, respectively. CONCLUSION: The IL-1 alpha-889 T/T and C/T genotypes are likely to be susceptible factors for the development of AD in Chinese Han population. The susceptibility genotype, female, and age > or =65 years are risk factors for AD.