参松养心胶囊对急性心肌梗死患者心率变异性的影响

目的探讨参松养心胶囊对急性心肌梗死患者心率变异性(HRV)的影响。方法将107例AMI治疗患者随机分为两组:参松养心胶囊加常规AMI治疗组(治疗组)58例,常规AMI对照组49例。治疗前进行HRV测定,两组间比较各指标均无显著性差异(P均>0.05),治疗1个疗程(28 d)后再次进行HRV测定。结果①治疗组:治疗后,正常R-R间期标准差(SDNN)2、4 h去Holter 5 min平均正常RR间期标准差(SDANN)2、4 h去Holter 5 min平均正常RR间期标准差的平均数(SDNNIDX)2、4 h去Holter正常相邻RR间期之差>50 ms的心搏数所占百分比(PNN50)、低频成分(LF)、高频成分(HF)、总功率谱(TP)较治疗前均显著升高(P均<0.01),LF/HF显著降低(P<0.01);②对照组:治疗后,SDANN、PNN50、LF、HF、TP较治疗前均显著升高(P均<0.05),LF/HF显著降低(P<0.05);③治疗后参松养心胶囊组与对照组比较SDANN、RMSSD、PNN50、LF、MF、HF、TP均显著升高(P均<0.05),LF/HF显著降低(P<0.05)。结论①常规AMI治疗(静脉溶栓、硝酸酯类及抗凝治疗),提高AMI患者的HRV;②参松养心胶囊加常规AMI治疗,对改善AMI患者HRV更显著,且能改善自主神经平衡性,改善预后。

Effection on Heart Rate Variety of AMI with Shensongyangxin Capsule

Objective To discuss the effection on heart rate variety(HRV) of AMI with Shensongyangxin capsule.Methods 107 cases of such patient were divided into 2 groups(therapy group 58 cases treated with this drug and control group 49 cases treated routinely).The HRV was detected before and 1 course after treatment.The result was compared.Results The SDNN,SDANN,SDNNIDX,PNN50,LF,HF and TP of RR after treatment were higher than those before treatment in therapy group.The SDANN,PNN50,LF,HF and TP were higher than those before treatment in control group(P<0.01) but LF/HF was lower(P<0.05).The SDNN,SDANN,SDNNIDX,PNN50,LF,HF and TP of RR were higher in therapy group than those in control group(P<0.01) but LF/HF was lower(P<0.05).Conclusion The routine therapy might improve the HRV and this drug added routine therapy might enhance effect and improve nerve balance and prognosis.