乌拉地尔大鼠小肠吸收实验确定其缓释制剂制备的基础理论研究

目的：本实验研究了乌拉地尔在大鼠小肠上、下部的吸收情况，为开发其缓释制剂提供依据。方法：采用高效液相色谱法。结果：回收率试验表明：乌拉地尔回收率为99．27％，精密度为0．8％。乌拉地尔在大鼠小肠上、下段的吸收速度常数Ka分别为0．269、0．272，T1／2分别为2．57、2．58和吸收率分别为27．55％、28．51％（P〉0．05）。结论：乌拉地尔在大鼠小肠上、下段的吸收率没有显著性差异，适合制备缓释制剂。

THE CHARACTER OF URAPIDIL SUSTAINED-RELEASE PREPARATIONS INTESTINE ABSORPTION IN RATS

Objective：To study the absorption of Urapidil in upper and lower rat＇s small intestine for reference of developiing sus- tained release preparations of urapidil. Methods ：The intestine in rats was cannulated for in situ recirculation. HPLC was used to det- emine the concentrations of phenolsulfonphthalein and Urapidil. Results： Urapidil＇s coefficient of recovery was 99. 27%, the degree of precision was 0, 8%, Ka（h-1） in upper and lower rat＇s small intestine was 0. 269 and 0. 272. T1/2（h） in upper and lower rats small intestine was 2. 57 and 2.58. Absorption in upper and lower rat＇s small intestine was 27.55% and 28.51% ,respectively（ P 〉 0. 05 ）.Conclusion：There was no significant difference between upper and lower rat＇s small intestine in absorption of urapidil and which thus suitable to be prepared into sustained release preparation.