nCPAP治疗对OSAHS患者CRP及IL-6水平的影响

目的探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者C反应蛋白（CRP）及白细胞介素-6（IL-6）水平的影响。方法选rcfhOSAHS患者50例，健康对照组50例，行多导睡眠监测后采静脉血检测CRP及IL-6，比较2组CRP、IL-6水平；对33例中、重度OSAHS行6个月nCPAP治疗，比较2组患者治疗前后CRP、IL-6水平变化。结果OSAHS组CRP、IL-6高于对照组（P〈0．05），夜间最低血氧饱和度（LSaO2）、夜间平均血氧饱和度（MSaO2）低于对照组（P〈0．05）；多元回归分析显示，CRP的影响因素为AHI、LSaO2、MSaO2，IL-6的影响因素为AHI、MSaO2（P〈0．05）；nCPAP治疗第7天CRP、IL-6与治疗前比较差异无统计学意义（P〉0．05），治疗3个月后CRP、IL-6较治疗前降低，差异有统计学意义（P〈0．05）。结论OSAHS患者CRP、IL-6升高，其增高主与OSAHS严重程度及夜间缺氧程度相关；长期nCPAP治疗可降低患者IL-6、CRP水平，减轻OSAHS患者全身炎症反应。

The study of therapeutic effects to C - reaction protein and Interleukin - 6 in patients with obstructive sleep apnea -hypopnea syndrome

Objective To study serum levels of c -reactive protein （CRP） and interleukin -6 （IL -6） in patients with obstructive sleep apnea -hypopnea syndrome （OSAHS）, and to explore the therapeutic effects of nasal continuous positive airway pressure （nCPAP） to CRP and IL - 6 in patients with OSAHS. Methods 50 OSAHS patients and 50 healthy controls were enrolled in study, all cases were received polysomnography and venous blood collection, serum level of CRP and IL - 6 were compared in two group, CRP and IL - 6 were compared before and after 6 months of nCPAP treatment in 33 moderate - to - severe OSAHS patients. Results CRP and IL - 6 were higher in OSAHS group （ P 〈 0.05 ）, and lowest SaO2 （ LSaO2 ） and mean SaO2 （ MSaO2 ） were lower in control group （ P 〈 0.05 ）. The multiple regression analysis showed that CRP was significantly correlated with AHI, LSaO2 and MSaO2 ; IL - 6 was significantly correlated with AHI and MSaO2 （ P 〈 0.05 ）. CRP and IL - 6 were no difference before and after 7 days of nCPAP treatment （ P 〉 0.05 ） , both CRP and IL - 6 were decreased significantly after 6 months of nCPAP treatment （ P 〈 0.05 ）. Conclusion CRP and IL - 6 is increased in patients with OSAHS, CRP and IL - 6 correlate with severity of OSAHS and hypoxia degree. CRP and IL - 6 obviously is decreased after long - term nCPAP treatment, nCPAP could improve inflammation in OSAHS patients.