Expression of stratified epithelial-type cytokeratins in hyalinizing trabecular adenomas supports their relationship with papillary carcinomas of the thyroid |
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Authors: | E. FONSECA,J.M. NESLAND,& M. SOBRINHO-SIMÕ ES |
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Affiliation: | Departments of Pathology, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal,;The Norwegian Radium Hospital and Institute for Cancer Research, University of Oslo, Oslo, Norway |
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Abstract: | Aim: To evaluate the cytokeratin pattern of expression of hyalinizing trabecular adenomas and to verify whether or not these tumours, that share morphological features with papillary carcinomas, present the stratified epithelial-type cytokeratins commonly found in ordinary papillary carcinomas. Methods and results: This study consisted of the immunohistochemical detection of simple and stratified epithelial type cytokeratin filaments in a series of six hyalinizing trabecular adenomas, three papillary carcinomas with a trabecular growth pattern and two carcinomas combining hyalinizing trabecular and papillary patterns. Simple epithelial-type cytokeratins 7, 8, 18 and 19 were found in every case. Expression of the stratified epithelial-type cytokeratins 1, 5/6 and/or 13 was detected in four hyalinizing trabecular adenomas. Conclusion: Based on this, as well as on the cytological features and on the frequent co-occurrence of hyalinizing trabecular adenoma and papillary carcinoma, we suggest that the former lesion may be considered a peculiar encapsulated variant of papillary carcinoma. |
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Keywords: | cytokeratin filaments hyalinizing trabecular adenoma papillary carcinoma |
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