Endogenous endotoxin absorption and the role of intestinal lymphatics |
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Authors: | Kaoru Azuma Morifumi Akiyama Toshiaki Ebata Morio Totsuka Hiroshi Hayasaka |
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Institution: | (1) Department of Surgery, Sapporo Medical College, Minami 1 Nishi 16, Chuo-ku, 060 Sapporo, Japan |
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Abstract: | We investigated the absorption routes of endotoxin derived from the intestine of rabbits with or without thoracic duct lymph
drainage (TDLD). The intestinal circulatory disorders induced were superior mesenteric artery occlusion (SMAO) and superior
mesenteric vein occlusion (SMVO). Detection and quantitation of endotoxin in plasma and lymph were carried out using a synthetic
chromogenic substrate (peptide-4-methyl-coumarin amide, MCA). In the SMAO group, endotoxin levels in portal plasma exceeded
levels in lymph from the thoracic duct throughout the experiment, and in the SMVO group, the relationship was reversed. In
peripheral arterial blood, endotoxin levels were significantly lower in rabbits with TDLD than in those with intact lymphatic
system. Intestinal lymphatics probably play an important role in appearance of systemic endotoxemia in non-septic shock. |
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Keywords: | endogenous endotoxin superior mesenteric artery occlusion (SMAO) superior mesenteric vein occlusion (SMVO) |
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