不同性状乳头溢液与乳管内病变的相关性探讨

目的：探讨不同性状乳头溢液与乳管内不同病变之间的相关性。方法对2007年3月~2012年3月在我院诊治的91例乳头溢液患者临床资料进行回顾性研究。结果91例乳头溢液患者中发现乳管内非占位性病变37例（40.7%）；占位性病变54例（59.3%），其中乳腺癌5例（5.5%）。与双侧、多孔、非血性乳头溢液患者相比，单侧、单孔、血性溢液患者更具有临床意义（P＜0.05）；与非咖啡样血性溢液相比，咖啡样血性溢液更具有临床意义（P＜0.01）。结论乳头溢液是乳管内病变的早期表现，也是早期乳腺癌的重要征象。不同性状乳头溢液与乳管内不同性质的疾病之间密切相关，应高度重视单侧、单孔、血性溢液，尤其是咖啡样乳头溢液。

The correlation of different characteristics of nipple discharge and intraductal lesions

Objective To explore the correlation of different characteristics of nipple discharge and intraductal lesions. Methods 91 cases with nipple discharge were admitted from Mar 2007 to Mar 2012 in our hospital. Their documents were an-alyzed retrospectively. Results 91 cases were successfully diagnozed and treated with the help of fiberoptic ductoscopy. 37 cases （40.7%）were diagnozed as non-protrusion lesions. 54 cases （59.3%）were diagnozed as protrusion lesions and performed operation. 5 cases （5.5%）of early breast cancer were confirmed by postoperative pathology. In comparison with bilateral, porous and no-bloody nipple discharge, there was more clinical significance in unilateral, single duct and bloody nipple discharge （P〈0.05）. Compared with non coffee like bloody discharge, there was more clinical significance in coffee nipple discharge（P〈0.01）. Conclusion Nipple discharge is an early manifestation of breast intraductal lesions, and also is the important sign of early breast cancer. There should be a closely relationship between different nipple discharge and breast intraductal lesions. More attention should be paid to the signs of unilateral, single duct and bloody nipple discharge, especially coffee nipple discharge.