阿莫西林联合碳酸铝镁片与兰索拉唑治疗消化道溃疡的临床观察

目的探讨消化道溃疡（PUD）患者行阿莫西林、兰索拉唑、碳酸铝镁片三联治疗后的临床效果与安全性。方法将我院2010年3月-2012年7月收治的212例PUD惠者作为研究对象，根据患者自愿原则分为研究组与对照组，其中研究组126例，对照组86例。对照组单纯采用兰索拉唑治疗，而研究组则采用三药联用的方式治疗，即兰索拉唑＋碳酸铝镁片＋阿莫西林联用治疗。我院针对两组患者采用不同方式治疗，疗程皆为40d左右（约为6周）。根据两组的疗效进行观察、分析，记录两组患者在治疗至第4周与第6周时相关数据，并做好对比。结果两组患者在治疗至第四周与第六周时，研究组治疗有效率分别为84．13％（106／126）、96．03％（121／126）；而对照组的治疗有效率则分别为69．77％（60／86）、86．05％（74／86），两组治疗有效率比较，差异有统计学意义（P〈0．05）；两组不良反应发生率比较，差异无统计学意义（P〉0．05）。结论阿莫西林、兰索拉唑、碳酸铝镁片三者联合应用于PUD的疗效确切，不良反应轻微，值得在临床上推广应用。

Clinical observation of amoxicillin aluminium magnesium carbonate tablets and lansoprazole in treating peptic ulcer

Objective To observe and discuss the clinical effect and safety in patients with peptic ulcer, lansoprazole, amoxicillin triple therapy of magnesium aluminium carbonate tablets after. Methods In our hospital from 2010 March to 2012 July, 212 patients received the peptic ulcer patients as the research object, according to the principle of voluntary patients were divided into study group and control group, 126 patients in the research group, 86 cases in the control group. The control group is treated with lansoprazole therapy, treatment and the study group with three drugs combined way, namely the lansoprazole ＋ aluminium magnesium carbonate ＋ amoxicillin for the treatment. Our hospital for two groups of patients with different treatment, the therapeutic course was 40 days （about 6 weeks）. Observation, according to the analysis of the therapeutic effect in the two groups, and record the two groups of patients in the treatment of 4 weeks and sixth weeks of data, and make a contrast. Results Two groups of patients in the treatment of 4 weeks and sixth weeks, the study group the treatment efficiency was 84.13% （106/126）, 96.03% （121/126）, and the effective rate of treatment group were 69.77% （60/86）, 86.05% （74/86）, the statistical analysis shows, two groups of treatment efficiency difference significantly （P〈0.05）, with statistical significance; similarly, the statistical analysis of the incidence of adverse reactions of the two groups, the difference is not significant （P〉0.05）, was not statistically significant.Conclusion The lansoprazole, amoxicillin, aluminium magnesium carbonate tablets three combination in peptic ulcer treatment efficacy, mild adverse reactions, it is worthy of clinical application.