Abnormal erythrocyte survival in patients with myotonic dystrophy |
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| Authors: | Olof Sydow Helena Stibler Robert Hast |
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| Institution: | Department of Neurology, Section of Hematology, Karolinska Hospital, Stockholm, Sweden;Department of Internal Medicine, Section of Hematology, Karolinska Hospital, Stockholm, Sweden |
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| Abstract: | In four of six patients with myotonic dystrophy whom we studied 51Cr labeled erythrocytes were found to have a biphasic survival kinetic. After in initial significantly more rapid disappearance than in controls, about 80% of the labeled cells reappeared in circulation, and were thereafter eliminated at a significantly faster rate than normal. This type of biphasic survival pattern may partly be related to reduced sialic acid concentration of the erythrocyte membrane in patients with this disease. |
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| Keywords: | Erythrocyte survival myotonic dystrophy sialic acid |
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