| 糖尿病大鼠味腺超微结构的研究 |
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| 引用本文： | 冯晓红,刘晓民,周立红,郑金华. 糖尿病大鼠味腺超微结构的研究[J]. 解剖学报, 2008, 39(2): 252-254 |
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| 作者姓名： | 冯晓红 刘晓民 周立红 郑金华 |
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| 作者单位： | 哈尔滨医科大学第一临床医院内分泌科;哈尔滨医科大学解剖学教研室,哈尔滨,150001 |
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| 摘 要： | 目的观察2型糖尿病大鼠味腺超微结构变化。方法雄性Wistar大鼠18只,随机分为对照组和实验组,高脂喂养加小剂量链脲佐菌素(STZ)腹腔注射制备2型糖尿病模型,饲养8周后取轮廓乳头,应用透射电镜观察味腺超微结构。结果与对照组大鼠比较,实验组大鼠味腺腺泡细胞的核膜凹陷、核固缩;线粒体嵴断裂、空泡变性;粗面内质网扩张,脱颗粒。结论糖尿病可导致味腺组织出现一系列超微结构病理改变,为进一步探讨糖尿病发生机制提供了形态学依据。
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| 关 键 词： | 糖尿病 味腺 超微结构 透射电镜 大鼠 |
| 收稿时间： | 2007-03-22 |
| 修稿时间： | 2007-03-22 |
ULTRASTRUCTURAL STUDIES ON VON EBNER'GLAND OF DIABETES RATS |
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| FENG Xiao-hong,LIU Xiao-min,ZHOU Li-hong,ZHENG Jin-hua. ULTRASTRUCTURAL STUDIES ON VON EBNER'GLAND OF DIABETES RATS[J]. Acta Anatomica Sinica, 2008, 39(2): 252-254 |
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| Authors: | FENG Xiao-hong LIU Xiao-min ZHOU Li-hong ZHENG Jin-hua |
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| Affiliation: | 1.Department of Endocrinology,the First Affiliated Hospital of Haerbin Medical University;2.Department of Anatomy, Haerbin Medical University, Haerbin 150001, China |
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| Abstract: | Objective To observe the ultrastructure changes on von Ebner's gland of type 2 diabetes rats. Methods Eighteen Wistar rats were randomly divided into control group and experiment group.The diabetes rats model were induced by intraperitoneal injection streptozotocin(STZ) after high-fat food.The von Ebner's gland ultrastructure was observed under transmission electron microscope(TEM) after 8 weeks. Results Compared with the control group,in diabetes rats acinar cell nucleus appeared nucleolemma introcession and karyopycnosis;mitochondria exhibited vacuole degeneration and crista breaking;rough endoplasmic reticula expanded and showed degranulation.Conclusion A sereies of pathologic changes in von Ebner's gland of diabetes rats can be induced by diabetes,which provides morphological evidences for further investigation on the mechanism of diabetes complication. |
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| Keywords: | Diabetes Von Ebner's gland Ultrastructure Transmission electron microscopy Rat |
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