环境内分泌干扰物与儿童性发育异常的相关性研究

目的：观察分析环境内分泌干扰物与儿童性发育异常的相关性。方法：选取我院从2010年3月至2013年3月专科门诊收治的性发育异常患儿共45例，同时选取同时期的正常儿童作为对照组共45例进行对比。采取入选受试者的血液样本检测其中的环境内分泌干扰物的含量情况。结果：观察组患儿的环境内分泌干扰物的含量明显要高于对照组儿童，其中辛基酚（OP）的保留时间为13．822min，双酚A的保留时间为11．942min。观察组有53．3％的患儿被检滑l出其体内含有辛基酚明显要高于对照组的6．67％；而观察组有48．9％的患儿其体内含有双酚A，明显要高于对照组儿童的8．89％。气相色谱中DBP的保留时间为13．623min，DEHP的保留时间为16．830min。其中观察组中有62．2％的患者检测出其体内含有DBP，明显高于对照组的8．89％，两组儿童对比有显著性差异；而DEHP则有57．8％的观察组患儿的血清中能够被检测到，明显要高于对照组的13．3％。结论：环境内分泌干扰素与儿童性发育异常的发生有着一定的相关性，应该尽量避免或者减少儿童接触环境内分泌干扰物，减少其对儿童性发育的影响。

Correlation of environmental endocrine disruptors and child sexual abnormalities

Objectives： To observe the correlation of environmental endocrine disruptors and child sexual abnormalities. Methods： 45 children with sexual abnormality admitted into our hospital from March 2010 to March 2013 were selected as the observation group, while 45 normal children in our hospital in the same period were cho- sen as the control group. The blood samples were tested to detect the content of environmental endocrine disruptors. Results： The content of environmental endocrine disruptors in the observation group was observed to be significantly higher than the control group, with the retention time of octylphenol （OP） and bisphenol A being 13. 822min and 11. 942min respectively. 53.3 % of the children in observation group were detected to have octylphenol, which was significantly higher than the 6.67% of the control group; while 48.9% of children in the observation group were found to have hisphenol A, which was significantly higher than the 8.89% of control group. Through gas chromatog- raphy, the retention time of DBP and DEHP was 13. 623min and 16. 830min respectively. 62.2 % of patients in the observation group were detected to have DBP, significantly higher than the 8.89% of the control group, with signifi- cant difference ; whereas serum DEHP was detected in 57.8 % of the children in the observation group, significantly higher than the 13.3% of the control group. Conclusion： Environmental endocrine disruptors and child sexual ab- normalities are of correlation. We should try to avoid or reduce children＇ s exposure to environmental endocrine dis- ruptors, hereby reducin~ its impact on children＇ s sexual development.