| HIV感染者、发病者及HAART治疗者NK细胞亚群变化研究 |
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| 引用本文： | 陈欢,何磊,张子宁,姜拥军,周方圆,刘静,韩晓旭,张日文,尚红.HIV感染者、发病者及HAART治疗者NK细胞亚群变化研究[J].免疫学杂志,2010(7). |
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| 作者姓名： | 陈欢 何磊 张子宁 姜拥军 周方圆 刘静 韩晓旭 张日文 尚红 |
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| 作者单位： | 中国医科大学附属第一医院卫生部艾滋病免疫学重点实验室; |
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| 基金项目： | 国家科技重大专项课题资助项目(2008ZX10001-001); 国家重点基础研究发展计划(2006CB504206); 辽宁省教育厅高等学校创新团队项目(辽教发[2008]117号) |
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| 摘 要： | 目的探讨HIV感染者、发病者和进行高效抗逆转录病毒疗法(HAART)的治疗者NK细胞亚群的变化情况。方法取新鲜外周全血,用荧光标记的单克隆抗体进行染色,经流式细胞仪检测分析HIV感染者、发病者和HAART治疗者NK细胞亚群的变化。结果 HIV感染者、发病者CD56dimCD16+NK细胞的百分比显著低于HIV抗体阴性健康对照;CD56-CD16+、CD56briCD16-/+NK细胞的百分比显著高于HIV抗体阴性健康对照;HAART治疗者CD56dimCD16+、CD56-CD16+和CD56briCD16-/+NK细胞亚群的百分比与HIV抗体阴性健康对照相比不再有显著差异。结论 HIV感染改变了NK细胞亚群的构成,HAART治疗后NK细胞亚群的比例可得到部分恢复。
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| 关 键 词： | NK细胞 亚群 HIV AIDS HAART |
Alteration of NK cell subsets in HIV-infected Chinese |
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| CHEN Huan,HE Lei,ZHANG Zining,JIANG Yongjun,ZHOU Fangyuan,LIU Jing,HAN Xiaoxu,ZHANG Min,SHANG Hong Key Laboratory of AIDS Immunology of Ministry of Health,First Affiliated Hospital,China Medical University,Shenyang ,China.Alteration of NK cell subsets in HIV-infected Chinese[J].Immunological Journal,2010(7). |
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| Authors: | CHEN Huan HE Lei ZHANG Zining JIANG Yongjun ZHOU Fangyuan LIU Jing HAN Xiaoxu ZHANG Min SHANG Hong Key Laboratory of AIDS Immunology of Ministry of Health First Affiliated Hospital China Medical University Shenyang China |
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| Institution: | CHEN Huan,HE Lei,ZHANG Zining,JIANG Yongjun,ZHOU Fangyuan,LIU Jing,HAN Xiaoxu,ZHANG Min,SHANG Hong Key Laboratory of AIDS Immunology of Ministry of Health,First Affiliated Hospital,China Medical University,Shenyang 110001,China |
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| Abstract: | To investigate changes of NK cell subsets in HIV-infected Chinese patients,PBMCs were collected from four groups representing different stages of HIV disease:asymptomatic chronically infected HIV patients,AIDS patients,HIV-positive patients receiving highly active antiretroviral therapy(HAART),and HIV-negative controls.PBMCs were stained with fluorescent monoclonal antibodies for the NK cell subsets.Three distinct subpopulations(CD56-CD16+,CD56dimCD16+ and CD56briCD16-/+) of NK cells were quantified by flow... |
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| Keywords: | NK cells subsets HIV AIDS HAART |
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