| Ezrin在转移性骨肿瘤中的表达及其与CD44V6表达的相关性 |
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| 引用本文： | 李宏,初同伟,周跃,张峡,潘勇,郝勇.Ezrin在转移性骨肿瘤中的表达及其与CD44V6表达的相关性[J].免疫学杂志,2010(3). |
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| 作者姓名： | 李宏 初同伟 周跃 张峡 潘勇 郝勇 |
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| 作者单位： | 第三军医大学新桥医院骨科; |
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| 摘 要： | 目的探讨人体转移性骨肿瘤组织中Ezrin和CD44v6表达之间的关系及Ezrin mRNA的表达与转移性骨肿瘤临床病理特征的关系。方法收集28例转移性骨肿瘤和12例良性骨肿瘤,应用免疫组织化学技术检测Ezrin和CD44v6的蛋白表达,应用RT-PCR检测Ezrin mRNA的表达情况。结果转移性骨肿瘤中Ezrin、CD44v6的蛋白阳性表达显著高于它们在良性骨肿瘤中的阳性表达(P<0.05);Ezrin和CD44v6的表达呈正相关(r=0.053,P<0.05);Ezrin mRNA的阳性表达与患者性别、年龄、有无原发灶和转移瘤部位无关,但与其分化程度有关。结论 Ezrin可能参与了转移性骨肿瘤的浸润、转移;Ezrin发挥作用可能需要与细胞粘附分子CD44v6相互作用;检测Ezrin的表达可作为转移性骨肿瘤生物学行为的一项评估指标。
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| 关 键 词： | Ezrin CD44v6 骨肿瘤 肿瘤转移 免疫组织化学 |
Expression of Ezrin in metastatic bone tumor and its correlation with CD44V6 |
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| LI Hong,CHU Tongwei,ZHOU Yue,ZHANG Xia,PAN Yong,HAO Yong.Expression of Ezrin in metastatic bone tumor and its correlation with CD44V6[J].Immunological Journal,2010(3). |
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| Authors: | LI Hong CHU Tongwei ZHOU Yue ZHANG Xia PAN Yong HAO Yong |
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| Institution: | LI Hong,CHU Tongwei,ZHOU Yue,ZHANG Xia,PAN Yong,HAO Yong Department of Orthopaedics,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China |
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| Abstract: | For investigating the clinical significance of Ezrin in metastatic bone tumor,we studied the expressions of Ezrin and CD44v6,as well as the correlation of between Ezrin expression levels and clinical pathologic characteristics of metastatic bone tumor.The expression of Ezrin and CD44v6 protein were detected in 28 cases of metastatic bone tumor and 12 cases of benign bone tumors by immunohistochemical method,while the expression of Ezrin mRNA was detected by RT PCR.These methods illustrated that the positive... |
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| Keywords: | Ezrin CD44V6 Bone tumor Neoplasm metastasis Immunohistochemistry |
| 本文献已被 CNKI 等数据库收录！ |
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