| 新型两亲性小分子——N-胆固醇基琥珀酰基氨基葡萄糖的合成及其自组装行为的初步研究 |
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| 引用本文： | 江倩,王银松,刘玲蓉,张其清. 新型两亲性小分子——N-胆固醇基琥珀酰基氨基葡萄糖的合成及其自组装行为的初步研究[J]. 国际生物医学工程杂志, 2002, 32(1): 142-145. DOI: 10.3760/cma.j.issn.1673-4181.2009.03.004 |
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| 作者姓名： | 江倩 王银松 刘玲蓉 张其清 |
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| 作者单位： | 中国医学科学院,北京协和医学院生物医学工程研究所,天津,300192;天津市生物医学材料重点实验室;福建省生物医学工程重点实验室,300070;天津医科大学药学院;中国医学科学院,北京协和医学院生物医学工程研究所,天津,300192;天津市生物医学材料重点实验室;厦门大学材料学院生物医学工程研究中心,361005;厦门市生物医学工程技术研究中心;福建省生物医学工程重点实验室; |
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| 基金项目： | 中央级公益型科研院所基本科研业务专项 |
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| 摘 要： | 目的:合成新型的两亲性小分子,并通过新的自组装方法制备其纳米材料.方法:用胆固醇对氨基匍萄糖进行疏水改性,使其具有两亲性;用核磁和红外表征目标产物N-胆固醇基琥珀酰基氨基葡萄糖(CSG)的化学结构,结合纳米共沉淀法和超声分散法制备其自组装体,并用扫描电镜、圆二色谱考察其自组装体的性质.结果:CSG通过这种新的方法形成具有高轴向比的纳米纤维状自组装体,分子在自组装过程中采取手性排列的方式.结论:通过设计分子的化学结构、控制自组装的方法和条件,可以得到先进的纳米材料.
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| 关 键 词： | 两亲性小分子 自组装 纳米材料 |
Preliminary study on the synthesis and self-assembly behavior of a new type of amphiphile N-cholesteryl succinyl glucosamine |
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| Abstract: | Objective To synthesize a new type of amphiphile and prepare its nano-materials through a new self-assembly method. Methods New type of amphiphile was synthesized by linking the cholesterol group as the hydrophobic group to a glucasamine moiety. The structures of the products were characterized by infrared rediation(IR) and nuclear magnetic resonance spectrometry(1H-NMR). A simple nanoprecipitation method and probe sonication method were adopted to prepare the N-cholesteryl succinyl glucosamine(CSG) self-assemblies.The self-assembly properties were investigated by SEM and CD. Results CSG exhibited a fibrous structure with high length-to-width ratio. CSG adopted the helical arrangement in the aggregation. Conclusion Novel nano-materials could be prepared by designing the structures of amphiphiles and controlling the self-assembly methods and conditions. |
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| Keywords: | AmphiphileSelf-assemblyNano-materials |
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