Prognostic significance of hepatocyte growth factor and c-MET expression in patients with diffuse large B-cell lymphoma |
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| Authors: | Kawano R Ohshima K Karube K Yamaguchi T Kohno S Suzumiya J Kikuchi M Tamura K |
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| Affiliation: | Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan. rrriiikkkoookawa@yahoo.co.jp |
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| Abstract: | The expression and prognostic significance of hepatocyte growth factor (HGF) and its receptor c-MET (MET proto-oncogene) was analysed in 96 cases of diffuse large B-cell lymphoma (DLBCL). Tissue sections were immunohistochemically stained for HGF and c-Met. The prognosis of HGF-positive and c-Met-positive cases was significantly worse than negative cases (HGF: P = 0.0036; c-Met: P = 0.0002). In addition, in the low-risk international prognostic index group, HGF-negative and c-Met-negative cases had a significantly better prognosis than positive cases (HGF: P = 0.0009; c-Met: P < 0.0001). Our results suggest that HGF/c-MET is a useful clinical marker of prognosis for patients with DLBCL. |
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| Keywords: | diffuse large B-cell lymphoma hepatocyte growth factor c-MET prognosis |
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