Evidence for oxidative/nitrosative stress in the pathogenesis of hepatic encephalopathy |
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Authors: | Chantal Bemeur Paul Desjardins Roger F Butterworth |
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Institution: | 1.Neuroscience Research Unit,H?pital Saint-Luc (CHUM) University of Montreal,Montreal,Canada;2.Neuroscience Research Unit,St-Luc Hospital (CHUM), University of Montreal,Montreal,Canada |
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Abstract: | Hepatic encephalopathy (HE) is a serious complication of liver failure. HE manifests as a series of neuropsychiatric and neuromuscular
symptoms including personality changes, sleep abnormalities, asterixis and muscle rigidity progressing through stupor to coma.
The pathophysiologic basis of HE remains unclear. There is general agreement that ammonia plays a key role. In recent years,
it has been suggested that oxidative/nitrosative stress constitutes part of the pathophysiologic cascade in HE. Direct evidence
for oxidative/nitrosative stress in the pathogenesis of HE has been demonstrated in experimental animal models of acute or
chronic liver failure. However, evidence from studies in HE patients is limited. This review summarizes this evidence for
a role of oxidative/nitrosative stress in relation to ammonia toxicity and to the pathogenesis of HE. |
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