A rare case of poorly differentiated endocrine cell carcinoma of the stomach with signet ring cell differentiation |
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Authors: | Souya Nunobe Hirokazu Taniguchi Hitoshi Katai Tadakazu Shimoda |
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Institution: | (1) Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan;(2) Department of Gastroenterological Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan;(3) Department of Pharmacy, Kagawa University Hospital, Kagawa, Japan;(4) Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Kagawa, Japan |
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Abstract: | There have been few reports of the dual differentiation of different cell types within the same gastric tumor. Here, we report
a rare case of poorly differentiated endocrine cell carcinoma with an associated differentiated signet ring cell population
arising in the stomach. The histological appearance of the tumor by light microscopy matched the phenotype of endocrine cell
carcinoma and signet ring cell differentiation with mucinous lakes. Cells with a phenotype intermediate between the two differentiated
cell types were also seen in the tumor. Both the endocrine cell carcinoma and the signet ring cells were diffusely positive
for chromogranin A and synaptophysin, a finding that is consistent with endocrine differentiation by immunohistochemical examination.
The patient’s postoperative clinical course had a poor prognosis, with aggressive tumor progression. Paraaortic lymph node
recurrence was found 6 months after the operation, and the patient died of the primary disease 16 months after the surgical
treatment. |
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