Pre-therapeutic 124I PET(/CT) dosimetry confirms low average absorbed doses per administered 131I activity to the salivary glands in radioiodine therapy of differentiated thyroid cancer期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Pre-therapeutic 124I PET(/CT) dosimetry confirms low average absorbed doses per administered 131I activity to the salivary glands in radioiodine therapy of differentiated thyroid cancer

Authors:	Walter Jentzen Robert F Hobbs Alexander Stahl Jochen Knust George Sgouros Andreas Bockisch

Institution:	1. Klinik für Nuklearmedizin, Universit?t Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany 2. Department of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA

Abstract:	Purpose Salivary gland impairment following high activity radioiodine therapy of differentiated thyroid cancer (DTC) is a severe side effect. Dosimetric calculations using planar gamma camera scintigraphy (GCS) with ¹³¹I and ultrasonography (US) provided evidence that the average organ dose per administered ¹³¹I activity (ODpA) is too low to account for observed radiation damages to the salivary glands. The objective of this work was to re-estimate the ODpA using ¹²⁴I PET(/CT) as a more reliable approach than ¹³¹I GCS/US.

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