Similar effects of substance P on learning and memory function between hippocampus and striatal marginal division |
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Authors: | Yan Yu Changchun Zeng Siyun Shu Xuemei Liu Chuhua Li |
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Institution: | [1]MOE Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, Guangdong Province, China [2]Institute of Cognitive Neuroscience, South China~Normal'University, Guangzhou, Guangdong Province, China [3]School of Life Science, South China Normal University, Guangzhou, Guangdong Province, China |
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Abstract: | Substance P is an endogenous neurokinin that is present in the central and peripheral nervous systems. The neuropeptide substance P and its high-affinity receptor neurokinin 1 receptor are known to play an important role in the central nervous system in inflammation, blood pressure, motor behavior and anxiety. The effects of substance P in the hippocampus and the marginal division of the striatum on memory remain poorly understood. Compared with the hippocampus as a control, immunofluorescence showed high expression of the substance P receptor, neurokinin 1, in the marginal division of the striatum of normal rats. Unilateral or bilateral injection of an antisense oligonucleotide against neurokinin 1 receptor mRNA in the rat hippocampus or marginal division of the striatum effectively reduced neurokinin 1 receptor expression. Independent of injection site, rats that received this antisense oligonucleotide showed obviously increased footshock times in a Y-maze test. These results indicate that the marginal division of the striatum plays a similar function in learning and memory to the hippocampus, which is a valuable addition to our mechanistic understanding of the learning and memory functions of the marginal division of the striatum. |
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Keywords: | nerve regeneration cognition substance P neurokinin 1 receptor hippocampus margin-al division of the striatum learning and memory neostriatum NSFC grant neural generation |
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