Variation in genes encoding eosinophil granule proteins in atopic dermatitis patients from Germany |
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Authors: | Qumar Parwez Susanne Stemmler Jörg T Epplen Sabine Hoffjan |
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Institution: | (1) Private medical practice, Gladbeck, Germany;(2) Department of Human Genetics, Ruhr-University, Bochum, Germany |
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Abstract: | Background Atopic dermatitis (AD) is believed to result from complex interactions between genetic and environmental factors. A main feature
of AD as well as other allergic disorders is serum and tissue eosinophilia. Human eosinophils contain high amounts of cationic
granule proteins, including eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN), eosinophil peroxidase
(EPO) and major basic protein (MBP). Recently, variation in genes encoding eosinophil granule proteins has been suggested
to play a role in the pathogenesis of allergic disorders. We therefore genotyped selected single nucleotide polymorphisms
within the ECP, EDN, EPO and MBP genes in a cohort of 361 German AD patients and 325 healthy controls. |
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