| Cicletanine与Bepridil对大鼠离体胸主动脉环收缩的抑制效应 |
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| 引用本文： | 朱铨英,姚炜,苏定冯.Cicletanine与Bepridil对大鼠离体胸主动脉环收缩的抑制效应[J].第二军医大学学报,1991(4). |
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| 作者姓名： | 朱铨英 姚炜 苏定冯 |
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| 作者单位： | 第二军医大学训练部药理学教研室 200433
(朱铨英)，第二军医大学军医系1987级 200433
(姚炜)，第二军医大学训练部药理学教研室 200433(苏定冯) |
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| 摘 要： | 采用雄性SD大鼠胸主动脉环标本,用累积给药法制备去甲肾上腺素(NE)与氯化钾(KCl)收缩主动脉环的量效曲线,观察Cicletanine(Cic)与Bepridil(Bep)的抑制效应,比较两者对NE或KCl最大收缩反应(E_(max))的抑制百分率(％)与ED_(50)。结果显示Cic主要抑制NE激动的主动脉环收缩;Bep主要抑制KCl激动的主动脉环收缩。Cic与Bep联孵时,Cic可增加Bep抑制NE激动主动脉环收缩的效应;Bep可增加Cic抑制KCl激动主动脉环收缩的效应。上述作用无内皮依赖性。
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| 关 键 词： | 抗高血压药 抗心律失常药 cicletanine bepridil 主动脉环 去甲肾上腺素 氯化钾 |
Inhibitory Effects of Cicletanine and Bepridil on the Contractions of Isolated Rat Thoracic Aorta Rings |
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| Zhu Quanying,Yao Wei,Su Dingfeng.Inhibitory Effects of Cicletanine and Bepridil on the Contractions of Isolated Rat Thoracic Aorta Rings[J].Academic Journal of Second Military Medical University,1991(4). |
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| Authors: | Zhu Quanying Yao Wei Su Dingfeng |
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| Abstract: | The inhibitory effects of cicletanine (Cic) and bepridil (Bep) on norepinephrine (NE)-and KCl-induced contractions were studied in isolated thoracic aorta rings of male Sprague-Dowley rats. It was found that Cic had a more potent effect on NE-induced contraction than on KCHnduced contraction. In. contrast, Bep had a more potent action on KCHnduced contraction. When the aorta rings were incubated with Cic and Bep, a potentialized inhibitory effect was observed on KCh but not NE-induced contractions. These effects were independent of the presence of endothelium. The results suggest that Cic and Bep have different action sites and properties on vascular smooth muscles. |
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| Keywords: | antihypertensive drugs antiarrhythmic drugs aorta rings bepridil cicletanine potassium chloride norepinephrine |
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