Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats |
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Authors: | Silveira D C Holmes G L Schachter S C Geula C Schomer D L |
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Institution: | Department of Neurology, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Enders #320, Boston, MA 02115, USA. silveira@a1.tch.harvard.edu |
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Abstract: | We investigated whether basal forebrain cholinergic neurons influence the expression of generalized seizures. Animals received intracerebroventricular injections of saporin (lesioned) or saline (controls) and were tested for susceptibility to flurothyl- or pentylenetetrazole-induced seizures. Lesioned rats had significantly shorter latencies to onset of generalized tonic-clonic seizures than controls. Our findings suggest that basal forebrain cholinergic neurons may participate in the modulation of generalized seizures. |
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Keywords: | Cholinergic system Saporin Epilepsy Flurothyl Pentylenetetrazole |
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